(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

Base Information

Chemical Name:(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide
CAS No.:1108600-44-7
Molecular Formula:C₁₈H₁₅Cl₂N₅O₃S
Molecular Weight:452.321
Hs Code.:

Synonyms:(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

Suppliers and Price of (1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

There total 5 articles about (1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1108600-43-6
(1S,5R)-6-tosyl-6-azabicyclo[3.2.0]hept-3-en-7-one

: 1108600-48-1
tetrabutylammonium 2,6-dichloropurin-9-ide

: 1108600-44-7
(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

Guidance literature:: tetrabutylammonium 2,6-dichloropurin-9-ide; With palladium diacetate; triisopropyl phosphite; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;

(1S,5R)-6-tosyl-6-azabicyclo[3.2.0]hept-3-en-7-one; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1108600-43-6
(1S,5R)-6-tosyl-6-azabicyclo[3.2.0]hept-3-en-7-one

: 1108600-48-1
tetrabutylammonium 2,6-dichloropurin-9-ide

: 1108600-44-7
(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

: 4-(2,6-dichloro-7H-purin-7-yl)-N-tosylcyclopent-2-enecarboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triisopropyl phosphite; In tetrahydrofuran; at 20 ℃; for 1.5h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2ob06775g

Reference yield:

: 97911-48-3,138127-85-2,146864-12-2,63838-48-2
(+/-)-6-azabicyclo[3.2.0]hept-3-en-7-one

: 1108600-44-7
(1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-tosylcyclopent-2-enecarboxamide

: 4-(2,6-dichloro-7H-purin-7-yl)-N-tosylcyclopent-2-enecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Novozyme_.(R). 435 / di-isopropyl ether; water / 12 h / 70 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triisopropyl phosphite / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; triisopropyl phosphite; In tetrahydrofuran; hexane; di-isopropyl ether; water;
DOI:10.1039/c2ob06775g