((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

Base Information

Chemical Name:((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
CAS No.:1360538-03-9
Molecular Formula:C₂₂H₂₆N₆O₂
Molecular Weight:406.487
Hs Code.:

Synonyms:((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

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Chemical Property of ((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

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Technology Process of ((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

There total 9 articles about ((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1108600-46-9
((1S,4R)-4-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

: 2393-23-9
4-methoxy-benzylamine

: 1360538-03-9
((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

Guidance literature:: In dimethyl sulfoxide; at 150 ℃;
DOI:10.1039/c2ob06775g

Reference yield:

: 97911-48-3,138127-85-2,146864-12-2,63838-48-2
(+/-)-6-azabicyclo[3.2.0]hept-3-en-7-one

: 1360538-03-9
((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: Novozyme_.(R). 435 / di-isopropyl ether; water / 12 h / 70 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triisopropyl phosphite / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / acetone / 20 °C

5.1: sodium tetrahydroborate; isopropyl alcohol / tetrahydrofuran / 1 h / 0 °C

6.1: ethanol / 5 h / 50 °C

7.1: dimethyl sulfoxide / 150 °C

With sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; triisopropyl phosphite; potassium carbonate; isopropyl alcohol; In tetrahydrofuran; ethanol; hexane; di-isopropyl ether; water; dimethyl sulfoxide; acetone;
DOI:10.1039/c2ob06775g

Reference yield:

: 146864-12-2
(1S,5R)-6-azabicyclo[3.2.0]hept-3-en-7-one

: 1360538-03-9
((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triisopropyl phosphite / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetone / 20 °C

4.1: sodium tetrahydroborate; isopropyl alcohol / tetrahydrofuran / 1 h / 0 °C

5.1: ethanol / 5 h / 50 °C

6.1: dimethyl sulfoxide / 150 °C

With sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; triisopropyl phosphite; potassium carbonate; isopropyl alcohol; In tetrahydrofuran; ethanol; hexane; dimethyl sulfoxide; acetone;
DOI:10.1039/c2ob06775g