4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Base Information

Chemical Name:4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester
CAS No.:345898-23-9
Molecular Formula:C₂₇H₃₁N₃O₈
Molecular Weight:525.558
Hs Code.:

4,N<sup>8</sup>-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Synonyms:4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Suppliers and Price of 4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

There total 6 articles about 4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 134067-82-6
4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid

: 345898-23-9
4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1246/bcsj.77.331

Reference yield:

: 1026498-24-7
methyl N-(4-hydroxybutyl)-β-alaninate

: 345898-23-9
4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3.00 g / Et₃N / tetrahydrofuran / 2.5 h / 20 °C

2.1: pyridine / 1 h / 0 °C

3.1: 1.33 g / NaN₃ / dimethylformamide / 1 h / 80 °C

4.1: PPh₃ / tetrahydrofuran; H₂O / 20 h / 20 °C

4.2: 79.5 percent / Na₂CO₃ / ethyl acetate; tetrahydrofuran; H₂O / 5 h / 20 °C

5.1: NaOH / methanol; H₂O / 1 h / 60 °C

6.1: EDC*HCl / dimethylformamide / 20 °C

With pyridine; sodium hydroxide; sodium azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.77.331

Reference yield:

: 345898-20-6
methyl 4-benzyloxycarbonyl-8-hydroxy-4-azaoctanoate

: 345898-23-9
4,N⁸-bis(benzyloxycarbonyl)-8-amino-4-azaoctanoic acid succinimidyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 1 h / 0 °C

2.1: 1.33 g / NaN₃ / dimethylformamide / 1 h / 80 °C

3.1: PPh₃ / tetrahydrofuran; H₂O / 20 h / 20 °C

3.2: 79.5 percent / Na₂CO₃ / ethyl acetate; tetrahydrofuran; H₂O / 5 h / 20 °C

4.1: NaOH / methanol; H₂O / 1 h / 60 °C

5.1: EDC*HCl / dimethylformamide / 20 °C

With pyridine; sodium hydroxide; sodium azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.77.331