2-(p-fluorophenyl)-6-nitrobenzoxazole

Base Information

• Chemical Name: 2-(p-fluorophenyl)-6-nitrobenzoxazole
• CAS No.: 1079992-36-1
• Molecular Formula: C₁₃H₇FN₂O₃
• Molecular Weight: 258.209
• Mol file: 1079992-36-1.mol

Synonyms:2-(p-fluorophenyl)-6-nitrobenzoxazole

Chemical Property of 2-(p-fluorophenyl)-6-nitrobenzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(p-fluorophenyl)-6-nitrobenzoxazole

There total 2 articles about 2-(p-fluorophenyl)-6-nitrobenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-Fluorobenzoic acid (456-22-4) + 5-Nitro-2-aminophenol (121-88-0) → 2-(p-fluorophenyl)-6-nitrobenzoxazole (1079992-36-1)

Guidance literature:

With PPA; Heating;

DOI:10.1016/j.ejmech.2008.04.001

Reference yield: 36.0%

6-nitrobenzo[d]oxazole (17200-30-5) + 4-fluorobenzoyl chloride (403-43-0) → 2-(p-fluorophenyl)-6-nitrobenzoxazole (1079992-36-1)

Guidance literature:

With hafnium-based metal-organic framework catalyst; In neat (no solvent); at 170 ℃; for 7h;

DOI:10.1016/j.jcat.2019.04.023

Reference yield: 45.0%

2-(p-fluorophenyl)-6-nitrobenzoxazole (1079992-36-1) → 6-amino-2-(p-fluorophenyl)benzoxazole (1134316-91-8)

Guidance literature:

With nickel(II) chloride hexahydrate; zinc; In methanol; at 60 ℃;

DOI:10.1016/j.ejmech.2008.04.001

upstream raw materials:

4-Fluorobenzoic acid

5-Nitro-2-aminophenol

6-nitrobenzo[d]oxazole

4-fluorobenzoyl chloride

Downstream raw materials:

6-amino-2-(p-fluorophenyl)benzoxazole