2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

Base Information

Chemical Name:2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester
CAS No.:79807-87-7
Molecular Formula:C₂₈H₂₉NO₆
Molecular Weight:475.541
Hs Code.:

Synonyms:2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

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Chemical Property of 2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

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Technology Process of 2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

There total 4 articles about 2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101-55-3
4-Bromodiphenyl ether

: 79807-87-7
2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg / 1.) diethyl ether, reflux, 3 h, 2.) a) diethyl ether, ice-bath temperature, 0.5 h, b) RT, 0.5 h, c) reflux, 0.5 h

2: 83 percent / PBr₃ / diethyl ether / 5 h / 0 °C

3: 1.) K₂CO₃ / 1.) DMF, 0.5 h, 2.) DMF, 10 h

4: cyclohexene / Pd/C / ethanol / 6 h / Heating

5: toluene / 6 h / Heating

With phosphorus tribromide; potassium carbonate; magnesium; cyclohexene; palladium on activated charcoal; In diethyl ether; ethanol; toluene;
DOI:10.1021/jm00343a011

Reference yield:

: 52446-51-2
2-(4-phenyloxyphenyl)ethyl alcohol

: 79807-87-7
2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / PBr₃ / diethyl ether / 5 h / 0 °C

2: 1.) K₂CO₃ / 1.) DMF, 0.5 h, 2.) DMF, 10 h

3: cyclohexene / Pd/C / ethanol / 6 h / Heating

4: toluene / 6 h / Heating

With phosphorus tribromide; potassium carbonate; cyclohexene; palladium on activated charcoal; In diethyl ether; ethanol; toluene;
DOI:10.1021/jm00343a011

Reference yield:

: 79807-86-6
1-(2-bromoethyl)-4-phenoxybenzene

: 79807-87-7
2-({3-[2-(4-Phenoxy-phenyl)-ethoxy]-phenylamino}-methylene)-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) K₂CO₃ / 1.) DMF, 0.5 h, 2.) DMF, 10 h

2: cyclohexene / Pd/C / ethanol / 6 h / Heating

3: toluene / 6 h / Heating

With potassium carbonate; cyclohexene; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00343a011