[2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester

Base Information

• Chemical Name: [2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester
• CAS No.: 1009081-53-1
• Molecular Formula: C₂₂H₂₆N₂O₅
• Molecular Weight: 398.459
• Mol file: 1009081-53-1.mol

Synonyms:[2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester

Chemical Property of [2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester

There total 1 articles about [2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

o-(methoxycarbonylmethyl)benzoic acid (14736-50-6) + N'-benzylhydrazinecarboxylic acid tert-butyl ester (53370-84-6) → [2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester (1009081-53-1)

Guidance literature:

o-(methoxycarbonylmethyl)benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

N'-benzylhydrazinecarboxylic acid tert-butyl ester; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1055/s-2007-990893

Reference yield: 88.0%

[2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester (1009081-53-1) → 2-benzyl-2,3-dihydro-5H-2,3-benzodiazepine-1,4-dione (1009081-55-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-2007-990893

upstream raw materials:

o-(methoxycarbonylmethyl)benzoic acid

N'-benzylhydrazinecarboxylic acid tert-butyl ester

Downstream raw materials:

2-benzyl-2,3-dihydro-5H-2,3-benzodiazepine-1,4-dione