14736-50-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Methoxy-2-Oxoethyl)benzoic acid is used as an intermediate in the production of various drugs for its ability to be incorporated into the molecular structures of pharmaceutical compounds, enhancing their therapeutic properties and efficacy.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(2-Methoxy-2-Oxoethyl)benzoic acid is used as a reagent for its capacity to participate in a range of chemical reactions, facilitating the synthesis of complex organic molecules and contributing to the development of novel chemical entities.
Used in Research:
2-(2-Methoxy-2-Oxoethyl)benzoic acid is employed as a research tool in organic chemistry and chemical synthesis, aiding scientists in understanding reaction mechanisms, exploring new synthetic pathways, and advancing the knowledge of organic compound behavior.

InChI:InChI=1/C10H10O4/c1-14-9(11)6-7-4-2-3-5-8(7)10(12)13/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 124-41-4 sodium methylate 
• 703-59-3 homophthalic anhydride 
• 118-90-1 ortho-methylbenzoic acid 
• 616-38-6 carbonic acid dimethyl ester 
• 95-13-6 1-indene 
• 169887-46-1 1-Hydroxy-4-methoxy-4,5-dihydro-1H-2,3-benzodioxepin 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 716-43-8 dimethyl homophthalate 
• 76-05-1 trifluoroacetic acid 
• 4090-69-1 3-methoxy-1H-isochromen-1-one 
• 89-51-0 Homophthalic acid 

Downstream Products

• 1026567-41-8 2-[3-(Diethoxy-phosphoryl)-2-oxo-propyl]-benzoic acid methyl ester 
• 104292-98-0 methyl 2-(1-methoxy-1-oxopropan-2-yl)benzoate 
• 83375-21-7 2-(7-Methoxy-4-oxo-4H-chromen-2-ylmethyl)-benzoic acid 
• 115706-46-2 2-(5-tert-Butoxycarbonyl-2,4-dioxo-pentyl)-benzoic acid 
• 83375-22-8 2-(7-Methoxy-5-methyl-4-oxo-4H-chromen-2-ylmethyl)-benzoic acid 
• 66298-59-7 methyl 2-ethoxycarbonylphenylacetate 
• 356558-47-9 (2-chlorocarbonyl-phenyl)-acetic acid methyl ester 
• 122775-46-6 1-(2-methoxycarbonylphenyl)-3-(2-N,N-diethylcarbamoylphenyl)acetone 
• 1009081-54-2 [2-(N-tert-butoxycarbonyl-N'-(4-nitrobenzenesulfonyl)hydrazinocarbonyl)phenyl]acetic acid methyl ester 
• 4090-69-1 3-methoxy-1H-isochromen-1-one 
• 1009081-53-1 [2-(N-benzyl-N'-tert-butoxycarbonylhydrazinocarbonyl)phenyl]acetic acid methyl ester 
• 1037296-85-7 methyl 2-[2-(chloroamino)phenyl]acetate 
• 1037296-82-4 methyl 2-[2-({[2-(2-methoxy-2-oxoethyl)anilino]carbonyl}amino)phenyl]acetate 
• 1037296-78-8 methyl 2-[2-(azidocarbonyl)phenyl]acetate 

Relevant academic research and scientific papers

Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites

Here we have described a systematic structure activity relationship (SAR) of a set of compounds inspired from cladosporin, a tool compound that targets parasite (Plasmodium falciparum) lysyl tRNA synthetase (KRS). Four sets of analogues, synthesized based on point changes in the chemical scaffold of cladosporin and other logical modifications and hybridizations, were assessed using high throughput enzymatic and parasitic assays along with in vitro pharmacokinetics. Co-crystallization of the most potent compound in our series (CL-2) with PfKRS revealed its structural basis of enzymatic binding and potency. Further, we report that CL-2 has performed better than cladosporin in terms of metabolic stability. It thus represents a new lead for further optimization toward the development of antimalarial drugs. Collectively, along with a lead compound, the series offers insights on how even the slightest chemical modification might play an important role in enhancing or decreasing the potency of a chemical scaffold.

Efficient flow fischer esterification of carboxylic acids with alcohols using sulfonic acid-functionalized silica as supported catalyst

Flow Fischer esterification of carboxylic acids using hydroxy-substituted sulfonic acid-functionalized silica (HOSAS) packed into a stainless steel column reactor was investigated. HO-SAS well catalyzed flow esterification of long chain carboxylic acids with methanol within 3min of residence time at 110°C, and the methyl esters were quantitatively obtained. The flow esterification protocol was applied to the synthesis of a variety of esters (19 examples) and scalable synthesis was also successful.

Highly chemoselective esterification reactions and Boc/THP/TBDMS discriminating deprotections under samarium(III) catalysis

The usefulness of SmCl3 as an excellent catalyst for chemoselective esterifications and selective removal of acid sensitive protecting groups such as Boc, THP, and TBDMS in the presence of one another is demonstrated through suitable examples.

Total synthesis of silyl-protected early intermediates of polyketide biosynthesis

The ketal-or dithioketal-protected isocoumarins 15-18 gave the corresponding 1-naphthols 21-26 in their reactions with the acetoacetate (10) or pentane-2, 4-dione (19) dianions and the acetone monoanion. Subjection of the dithioketal-protected ester 28 to

The chemistry of homophthalic acid: a new synthetic strategy for construction of substituted isocoumarin and indole skeletons

Homophthalic acid was reacted with thionylchloride/DMF and chloroethylformate/NEt3 in the presence and absence of NaN3. In all cases completely different isocoumarin derivatives were obtained. These unusual isocoumarin derivatives were isolated and characterized and their formation mechanisms are discussed. The homophthalic acid monomethyl ester was converted into the corresponding isocyanate. Reaction of the isocyanate with different amines produced the urea derivatives. Base-supported condensation reactions of these products gave first an indolinone derivative, which underwent further intermolecular condensation to give substituted indole derivatives. However, when the condensation reaction was carried out in the presence of acetic anhydride, the intermolecular reactions were suppressed. This methodology opens up a new way of synthesizing of various five-membered ring substituted indole derivatives.

A domino N-amidoacylation/aldol-type condensation approach to the synthesis of the topo-I inhibitor rosettacin and derivatives

(Chemical Equation Presented) The pot, atom, and step-economic synthesis of Rosettacin topo-I poison and its derivatives has been achieved using a novel domino N-amidoacylation/aldol-type condensation, followed by decarboxylation of the ester function. Th

Synthesis and reactivity of 2,3-dihydro-1H-2,3-benzodiazepine-1,4(5H)-dione

Based on an orthogonal protective group strategy dealing with N-protected hydrazine, we established for the first time a highly efficient synthetic pathway leading to 2,3-benzodiazepine-1,4-dione. Moreover, the versatile reactivities exhibited by this 2,3

Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors

Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as heterocyclic derivatives were evaluated against representative members of zinc-dependent aminopeptidases: leucine aminopeptidase (E.C. 3.4.11.1), aminopeptidase-N (E.C. 3.4.11.2), Aeromonas proteolytica aminopeptidase (E.C. 3.4.11.10), and the aminopeptidase activity of leukotriene A4 hydrolase (E.C. 3.3.2.6). Several compounds showed Ki values in the low micromolar range against the 'one-zinc' aminopeptidases, while most of them were rather poor inhibitors of the 'two-zinc' enzymes. This interesting selectivity profile may guide the design of new, specific inhibitors of target mammalian aminopeptidases with one active site zinc.

Ozonolysis of enol ethers. Part 10. Ozonization of enol ethers from 1,2- and 1,3-dicarbonyl compounds: Direct quantitative synthesis of phthalonic acid anhydride

The results of ozonolyses of enol ethers from 1.2- and 1.3-dicarbonyl compounds presented here strongly indicate that these reactions do not proceed via the established Criegee ozonolysis mechanism for nucleophilic C=C bonds. The quantitative one-step synthesis of phthalonic acid anhydride via ozonolysis of 2-(methoxymethyliden)-1H-inden-1.3(2H)-dione (28a) is described. Furthermore, a revision of the theory of alkene ozonolysis in the presence of tetracyanoethylene (TCNE) is proposed on the basis of a single-electron-transfer (SET) chemistry.

Highly efficient esterification of carboxylic acids with alcohols by montmorillonite enwrapped titanium as a heterogeneous acid catalyst

Montmorillonite-enwrapped titanium catalyst was found to efficiently promote the esterification of carboxylic acids with alcohols. In comparison to other catalysts reported to date, this heterogeneous catalyst offers a remarkably simple workup procedure, and is reusable without any appreciable loss in its activity and selectivity.