ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene

Base Information

• Chemical Name: ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene
• CAS No.: 1445994-79-5
• Molecular Formula: C₂₇H₃₀O₇
• Molecular Weight: 466.531
• Mol file: 1445994-79-5.mol

Synonyms:ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene

Chemical Property of ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene

There total 4 articles about ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ent-6β,14α-dihydroxy-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene (16763-48-7) + benzoic acid (65-85-0,8013-63-6) → ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene (1445994-79-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃;

DOI:10.1016/j.fitote.2014.10.005

Reference yield:

oridonin → ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene (1445994-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium periodate / water / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

With dmap; sodium periodate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;

DOI:10.1016/j.ejmech.2013.04.012

Reference yield:

oridonin (28957-04-2,28957-10-0) → ent-6β-hydroxy-14α-O-(benzoyl)-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene (1445994-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium periodate / water / 24 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 20 °C

With sodium periodate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water;

DOI:10.1016/j.fitote.2014.10.005

upstream raw materials:

ent-6β,14α-dihydroxy-1,7-epoxy-7,15-dioxo-6,20-hemiketal-6,7-seco-16-kaurene

benzoic acid

oridonin