(R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

Base Information

Chemical Name:(R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one
CAS No.:327165-40-2
Molecular Formula:C₁₉H₂₇NO₃Si
Molecular Weight:345.514
Hs Code.:

Synonyms:(R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

There total 6 articles about (R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: C₁₄H₂₆O₃Si

: 327165-40-2
(R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

Guidance literature:: (R)-4-(phenylmethyl)-2-oxazolidinone; With n-butyllithium; 1,10-Phenanthroline; In tetrahydrofuran; hexane; at -78 ℃;

C₁₄H₂₆O₃Si; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1021/ja048493l

Reference yield:

: 120417-01-8
<1-(acetyloxy)-2-methyl-2-propenyl>trimethylsilane

: 327165-40-2
(R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: i-Pr₂NEt / CH₂Cl₂ / 72 h / 20 °C

2.1: aq. LiOH / methanol / 3 h / 0 - 23 °C

3.1: Et₃N / diethyl ether / 1 h / 23 °C

4.1: 1,10-phenanthroline; n-BuLi / tetrahydrofuran; hexane / -78 °C

4.2: 14.9 g / tetrahydrofuran; hexane / 0.5 h / -78 °C

With lithium hydroxide; n-butyllithium; 1,10-Phenanthroline; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; 1.1: Ireland-Claisen rearrangement;
DOI:10.1021/ja048493l

Reference yield:

: 327165-39-9
tert-butyldimethylsilyl (E)-4-methyl-5-trimethylsilyl-4-pentenoate

: 327165-40-2
(R)-4-benzyl-3-[(E)-4-methyl-5-(trimethylsilanyl)pent-4-enoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. LiOH / methanol / 3 h / 0 - 23 °C

2.1: Et₃N / diethyl ether / 1 h / 23 °C

3.1: 1,10-phenanthroline; n-BuLi / tetrahydrofuran; hexane / -78 °C

3.2: 14.9 g / tetrahydrofuran; hexane / 0.5 h / -78 °C

With lithium hydroxide; n-butyllithium; 1,10-Phenanthroline; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1021/ja048493l