7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one

Base Information

• Chemical Name: 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one
• CAS No.: 1450604-36-0
• Molecular Formula: C₂₇H₂₇NO₄
• Molecular Weight: 429.516

Synonyms:7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one

Chemical Property of 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one

There total 8 articles about 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7-(2-bromoethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one (1450604-24-6) + diethylamine (109-89-7) → 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one (1450604-36-0)

Guidance literature:

In tetrahydrofuran; at 120 ℃; for 0.5h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.bmcl.2013.07.009

Reference yield:

4-hydroxy-benzoic acid (99-96-7) → 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one (1450604-36-0)

Guidance literature:

Multi-step reaction with 5 steps

1: trichlorophosphate; zinc(II) chloride / sulfolane / 2 h / 65 °C

2: triethylamine / 0.5 h / 130 °C / Microwave irradiation

3: hydrogenchloride; water / acetone / Reflux

4: potassium carbonate / acetone / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

5: tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

With hydrogenchloride; water; potassium carbonate; triethylamine; zinc(II) chloride; trichlorophosphate; In tetrahydrofuran; sulfolane; acetone;

DOI:10.1016/j.bmcl.2013.07.009

Reference yield:

recorcinol (108-46-3) → 7-(2-(diethylamino)ethoxy)-4-(4-hydroxyphenyl)-3-phenyl-2H-chromen-2-one (1450604-36-0)

Guidance literature:

Multi-step reaction with 5 steps

1: trichlorophosphate; zinc(II) chloride / sulfolane / 2 h / 65 °C

2: triethylamine / 0.5 h / 130 °C / Microwave irradiation

3: hydrogenchloride; water / acetone / Reflux

4: potassium carbonate / acetone / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

5: tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation; Sealed tube

With hydrogenchloride; water; potassium carbonate; triethylamine; zinc(II) chloride; trichlorophosphate; In tetrahydrofuran; sulfolane; acetone;

DOI:10.1016/j.bmcl.2013.07.009

upstream raw materials:

4-(7-acetoxy-2-oxo-3-phenyl-2H-chromen-4-yl)phenyl acetate

2,4,4'-trihydroxy-benzophenone

recorcinol

4-hydroxy-benzoic acid

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