(S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one

Base Information

• Chemical Name: (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one
• CAS No.: 1450741-61-3
• Molecular Formula: C₃₀H₃₅IO₇
• Molecular Weight: 634.508

Synonyms:(S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one

Chemical Property of (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one

There total 10 articles about (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)phenyl)-3-methylbutan-2-one (1450741-60-2) → (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one (1450741-61-3)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; at 0 - 20 ℃; for 1.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol402191t

Reference yield:

3,5-bis((benzyloxy)methoxy)-4-bromo-1-(E)-prop-1-en-1-ylbenzene (1450741-55-5) → (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one (1450741-61-3)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium diacetate; ruphos; potassium carbonate / toluene; water / 1.5 h / 85 °C / Inert atmosphere; Schlenk technique

2: tetrahydrofuran; diethyl ether / 0.25 h / -78 - 0 °C / Inert atmosphere; Schlenk technique

3: hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); potassium osmate; potassium carbonate; methanesulfonamide / water; tert-butyl alcohol / 18 h / 20 °C / Inert atmosphere; Schlenk technique

4: iodine; silver trifluoroacetate / chloroform / 1.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With potassium osmate; methanesulfonamide; iodine; palladium diacetate; silver trifluoroacetate; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); ruphos; In tetrahydrofuran; diethyl ether; chloroform; water; toluene; tert-butyl alcohol; 1: |Suzuki Coupling / 3: |Sharpless Dihydroxylation;

DOI:10.1021/ol402191t

Reference yield:

3,5-bis((benzyloxy)methoxy)-4-bromobenzaldehyde (1450741-54-4) → (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one (1450741-61-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 18-crown-6 ether; potassium tert-butylate / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: palladium diacetate; ruphos; potassium carbonate / toluene; water / 1.5 h / 85 °C / Inert atmosphere; Schlenk technique

3: tetrahydrofuran; diethyl ether / 0.25 h / -78 - 0 °C / Inert atmosphere; Schlenk technique

4: hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); potassium osmate; potassium carbonate; methanesulfonamide / water; tert-butyl alcohol / 18 h / 20 °C / Inert atmosphere; Schlenk technique

5: iodine; silver trifluoroacetate / chloroform / 1.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With potassium osmate; 18-crown-6 ether; methanesulfonamide; potassium tert-butylate; iodine; palladium diacetate; silver trifluoroacetate; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III); ruphos; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; toluene; tert-butyl alcohol; 1: |Wittig Olefination / 2: |Suzuki Coupling / 4: |Sharpless Dihydroxylation;

DOI:10.1021/ol402191t

upstream raw materials:

(benzyloxy)methyl 3,5-bis((benzyloxy)methoxy)-4-bromobenzoate

(3,5-bis((benzyloxy)methoxy)-4-bromophenyl)methanol

3,5-bis((benzyloxy)methoxy)-4-bromobenzaldehyde

3,5-bis((benzyloxy)methoxy)-4-bromo-1-(E)-prop-1-en-1-ylbenzene

Downstream raw materials:

C₃₇H₅₀O₈Si₂

C₄₆H₅₈O₁₁Si

(S)-5,7-bis((benzyloxy)methoxy)-6-((2S,5R,7S)-5-hydroxy-7-((4-methoxybenzyl)oxy)-2-methyl-3-oxooctyl)-3-((S)-1-hydroxyethyl)isobenzofuran-1(3H)-one

(S)-5,7-bis((benzyloxy)methoxy)-3-((S)-1-hydroxyethyl)-6-((S)-2-methyl-3-oxobutyl)isobenzofuran-1(3H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1450741-61-3 (S)-4-(2,6-bis((benzyloxy)methoxy)-4-((1S,2S)-1,2-dihydroxypropyl)-3-iodophenyl)-3-methylbutan-2-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send