(2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone

Base Information

Chemical Name:(2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone
CAS No.:312513-29-4
Molecular Formula:C₁₅H₁₀O₅
Molecular Weight:270.241
Hs Code.:
DSSTox Substance ID:DTXSID501202113
Pharos Ligand ID:S3BF49K8Z98N
ChEMBL ID:CHEMBL2314710

Synonyms:CHEMBL2314710;(2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone;312513-29-4;Oprea1_176763;DTXSID501202113;HMS1618E01;BDBM50425971;STK662503;AKOS003827106;EU-0017163;SR-01000115076;SR-01000115076-1;(2,5-Dihydroxyphenyl)(5-hydroxy-3-benzofuranyl)methanone

Suppliers and Price of (2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:270.05282342
Heavy Atom Count:20
Complexity:371

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1O)C(=O)C2=COC3=C2C=C(C=C3)O)O

Technology Process of (2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone

There total 6 articles about (2,5-Dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 169944-36-9
(2,5-dimethoxyphenyl)(5-hydroxybenzofuran-3yl)methanone

: 312513-29-4
5-hydroxy-3-(2,5-dihydroxybenzoyl)benzo[b]furan

: 1426074-90-9
(2-hydroxy-5-methoxyphenyl)(5-hydroxybenzofuran-3-yl)methanone

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.jnatprod.9b00681

Reference yield:

: 169944-36-9
(2,5-dimethoxyphenyl)(5-hydroxybenzofuran-3yl)methanone

: 312513-29-4
5-hydroxy-3-(2,5-dihydroxybenzoyl)benzo[b]furan

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 0 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.12.026

Reference yield:

: 1201-38-3
2',5'-dimethoxyacetophenone

: 312513-29-4
5-hydroxy-3-(2,5-dihydroxybenzoyl)benzo[b]furan

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 8 h / 120 °C / Inert atmosphere

2: acetic acid / 3 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 2.5 h / -78 - 0 °C / Inert atmosphere

With boron tribromide; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.12.026