1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl )-5,6,7,8-tetrahydro-alpha-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, ( R,S)-(+/-)-

Base Information

Chemical Name:1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl )-5,6,7,8-tetrahydro-alpha-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, ( R*,S*)-(+/-)-
CAS No.:114621-94-2
Molecular Formula:C₂₅H₃₁NO₇
Molecular Weight:457.524
Hs Code.:
Mol file:114621-94-2.mol

1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl )-5,6,7,8-tetrahydro-alpha-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, ( R*,S*)-(+/-)-

Synonyms:1,3-Dioxolo[4,5-g]isoquinoline-5-methanol,6-(2,2-dimethyl-1-oxopropyl)-5,6,7,8-tetrahydro-a-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, (R*,S*)-(9CI); 1,3-Dioxolo[4,5-g]isoquinoline-5-methanol,6-(2,2-dimethyl-1-oxopropyl)-5,6,7,8-tetrahydro-a-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, (R*,S*)-(?à)-

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Chemical Property of 1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl )-5,6,7,8-tetrahydro-alpha-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, ( R*,S*)-(+/-)-

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Technology Process of 1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl )-5,6,7,8-tetrahydro-alpha-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, ( R*,S*)-(+/-)-

There total 6 articles about 1,3-Dioxolo[4,5-g]isoquinoline-5-methanol, 6-(2,2-dimethyl-1-oxopropyl )-5,6,7,8-tetrahydro-alpha-[2-(hydroxymethyl)-3,4-dimethoxyphenyl]-, ( R*,S*)-(+/-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: u-6,7-Dimethoxy-3-(1',2',3',4'-tetrahydro-6',7'-(methylendioxy)-2'-pivaloylisochinolin-1'-yl)-1(3H)-isobenzofuranone

: 114621-94-2
u-(tert-Butyl)-<1,2,3,4-tetrahydro-1-(α-hydroxy-2-hydroxymethyl-3,4-dimethoxybenzyl)-6,7-methylendioxyisochinolin-2-yl>-keton

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; for 1h;
DOI:10.1002/hlca.19870700517

Reference yield:

: 55171-60-3
2-bromo-3,4-dimethoxybenzylaldehyde

: 114621-94-2
u-(tert-Butyl)-<1,2,3,4-tetrahydro-1-(α-hydroxy-2-hydroxymethyl-3,4-dimethoxybenzyl)-6,7-methylendioxyisochinolin-2-yl>-keton

Guidance literature:: Multi-step reaction with 5 steps

1: Amberlyst 15 / 1 h / Ambient temperature

2: BuLi / tetrahydrofuran / -100 deg C --> 20 deg C, overnight

3: Amberlyst-15 / acetone; H₂O

4: 63 percent / 8 h

5: 70 percent / NaAlH₂(OCH₂CH₂OCH₃)2 / tetrahydrofuran / 1 h

With n-butyllithium; Amberlyst 15; amberlyst-15; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; water; acetone;
DOI:10.1002/hlca.19870700517

Reference yield:

: 104270-87-3
6-Formyl-2,3-dimethoxybenzoesaeure-ethylester

: 114621-94-2
u-(tert-Butyl)-<1,2,3,4-tetrahydro-1-(α-hydroxy-2-hydroxymethyl-3,4-dimethoxybenzyl)-6,7-methylendioxyisochinolin-2-yl>-keton

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / 8 h

2: 70 percent / NaAlH₂(OCH₂CH₂OCH₃)2 / tetrahydrofuran / 1 h

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran;
DOI:10.1002/hlca.19870700517