104270-87-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 6-formyl-2,3-dimethoxy-, ethyl ester is used as an intermediate in the synthesis of (+/-)-β-Hydrastine (H675690), which is an inhibitor of dopamine biosynthesis. This makes it a valuable compound in the development of medications targeting dopamine-related disorders.
Used in Chemical Synthesis:
Benzoic acid, 6-formyl-2,3-dimethoxy-, ethyl ester can also be used as a starting material or intermediate in the synthesis of other organic compounds, particularly those with potential applications in various industries such as pharmaceuticals, agrochemicals, and materials science. Its unique structure allows for further functionalization and modification to create new molecules with specific properties and applications.

Upstream product

• 519-05-1 opianic acid 
• 64-17-5 ethanol 
• 124-38-9 carbon dioxide 
• 59276-33-4 veratraldehyde dimethyl acetal 
• 55171-60-3 2-bromo-3,4-dimethoxybenzylaldehyde 
• 132234-28-7 2-Brom-3,4-dimethoxybenzaldehyd-dimethyl-acetal 
• 75-03-6 ethyl iodide 

Downstream Products

• 79677-12-6 ethyl 6-(4,6-dihydroxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,3-dimethoxybenzoate 
• 79677-11-5 6-(2-Benzyl-4,6-dihydroxy-1,2,3,4-tetrahydro-isoquinolin-1-yl)-2,3-dimethoxy-benzoic acid 
• 144192-17-6 ethyl 2-methyl-5,6-dimethoxybenzoate 
• 315678-11-6 6-[1,3]dithiolan-2-yl-2,3-dimethoxy-benzoic acid ethyl ester 
• 123796-70-3 3,4-dimethoxy-2-carbethoxybenzoic acid 
• 1201907-00-7 ethyl 2-(1,3-dithian-2-yl)-5,6-dimethoxybenzoate 
• 123796-72-5 6-(6,7-Dimethoxy-3,4-dihydro-isoquinoline-1-carbonyl)-2,3-dimethoxy-benzoic acid ethyl ester 
• 123796-73-6 6-(7,8-Dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonyl)-2,3-dimethoxy-benzoic acid ethyl ester 
• 79677-13-7 6-(4,6-dihydroxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,3-dimethoxybenzoic acid 
• 2934-97-6 (+/-)-tetrahydropalmatine 
• 144192-18-7 5,6-dimethoxy-2-((trimethylsilyl)methyl)benzoic acid 
• 144192-16-5 5,6-dimethoxy-2-((trimethylsilyl)methyl)benzoyl chloride 
• 5653-57-6 2-methyl-5,6-dimethoxybenzoic acid 
• 114621-94-2 u-(tert-Butyl)-<1,2,3,4-tetrahydro-1-(α-hydroxy-2-hydroxymethyl-3,4-dimethoxybenzyl)-6,7-methylendioxyisochinolin-2-yl>-keton 

Relevant academic research and scientific papers

New efficient route to fused aryltetrahydroindolizinones via N-Acyliminium intermediates

Straightforward routes to fused tetrahydroindolizinones by two routes A and B, starting either from. 2-formylbenzoic acid and esters or from, β-hydroxy lactones via acyl iminium ions, are described. A plausible mechanism and limitations are given. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009.

First Rational Synthesis of the Thiothiono Analogue of an Unsymmetrically Substituted Phthalic Anhydride

equation presented Treatment of the dithiolane derivative of an α-carboxyethyl benzaldehyde with LDA at -78°C smoothly produced the thiothionophthalic anhydride. The mechanism is proposed to involve loss of ethene and attack of an intermediate dithiocarboxylate onto the ester. Heating the thiothionophthalic anhydride gave the 3,3′-bithiophthalide.

Diastereoselektive Hydroxyalkylierungen in 1-Stellung von Tetrahydroisochinolinen und Synthese von Aporphin-, Protoberberin- und Phthalid-Alkaloiden

Unsubstituted and 6,7-dialkyloxy-N-pivaloyl-tetrahydroisoquinolines 1-3 are converted to 1-bromomagnesium derivatives by sequential treatment with t-BuLi (-75 deg C/THF) and MgBr2*OEt2.Addition of the metalated tetrahydroisoquinolines to aliphatic or arom