4-Methyl-3-(trifluoromethyl)phenol

Base Information

• Chemical Name: 4-Methyl-3-(trifluoromethyl)phenol
• CAS No.: 1017778-16-3
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.138
• Hs Code.: 2907199090
• European Community (EC) Number: 684-582-7

Synonyms:4-Methyl-3-(trifluoromethyl)phenol;1017778-16-3;MFCD09832294;starbld0017216;SCHEMBL10034978;AC7998;AKOS011050330;MB07749;5-HYDROXY-2-METHYLBENZOTRIFLUORIDE;SY228690;TS-02431;DB-154242;CS-0439943;EN300-204254

Chemical Property of 4-Methyl-3-(trifluoromethyl)phenol

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 176.04489933
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

99%, ^*data from raw suppliers

4-Methyl-3-(trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)O)C(F)(F)F

Technology Process of 4-Methyl-3-(trifluoromethyl)phenol

There total 1 articles about 4-Methyl-3-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-bromo-1-methyl-2-(trifluoromethyl) benzene (86845-27-4) → 4-methyl-3-(trifluoromethyl)phenol (1017778-16-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; In 1,4-dioxane; water; at 100 ℃; for 2.5h; Inert atmosphere;

Reference yield: 59.0%

3,5-dibromo-1-(propan-2-yl)-1H-1,2,4-triazole (1240567-67-2) + 4-methyl-3-(trifluoromethyl)phenol (1017778-16-3) → 3-bromo-5-[4-methyl-3-(trifluoromethyl)phenoxy]-1-(propan-2-yl)-1H-1,2,4-triazole

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

4-methyl-3-(trifluoromethyl)phenol (1017778-16-3) + acetic anhydride (108-24-7) → 4-methyl-3-(trifluoromethyl)phenyl acetate (1422129-77-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

4-bromo-1-methyl-2-(trifluoromethyl) benzene

Downstream raw materials:

4-(bromomethyl)-3-(trifluoromethyl)phenyl acetate

4-methyl-3-(trifluoromethyl)phenyl acetate

(5Z)-5-({1-[4-hydroxy-2-(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-(prop-2-yn-1-ylamino)-1,3-thiazol-2(5H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1017778-16-3 4-methyl-3-(trifluoromethyl)phenol

Send

Send

Metric Ton KG G Pound L ML

Send

Send