[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride

Base Information

• Chemical Name: [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride
• CAS No.: 246240-20-0
• Molecular Formula: C₁₉H₁₂Cl₂N₂O₃
• Molecular Weight: 387.222

Synonyms:[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride

Chemical Property of [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride

Chemical Property:

Purity/Quality:

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Technology Process of [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride

There total 4 articles about [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetic acid (246238-45-9) → [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride (246240-20-0)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 1h;

DOI:10.1016/S0960-894X(02)00051-3

Reference yield:

(3-amino-phenyl)-acetic acid methyl ester (52913-11-8) → [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride (246240-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / pyridine; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 53 percent / 2 N NaOH / methanol; dimethylformamide / 2 h / 25 °C

3: 100 percent / (COCl)2 / CH₂Cl₂ / 1 h

With pyridine; dmap; sodium hydroxide; oxalyl dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00051-3

Reference yield:

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride (69399-79-7) → [3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetyl chloride (246240-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / pyridine; DMAP / CH₂Cl₂ / 3 h / 25 °C

2: 53 percent / 2 N NaOH / methanol; dimethylformamide / 2 h / 25 °C

3: 100 percent / (COCl)2 / CH₂Cl₂ / 1 h

With pyridine; dmap; sodium hydroxide; oxalyl dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00051-3

upstream raw materials:

[3-(9-chloro-3-methyl-4-oxo-4H-isoxazolo[4,3-c]quinolin-5-yl)-phenyl]-acetic acid

(3-amino-phenyl)-acetic acid methyl ester

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

(3-{[3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-phenyl)-acetic acid methyl ester

Downstream raw materials:

LY 402913

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