4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

Base Information

Chemical Name:4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide
CAS No.:1345879-58-4
Molecular Formula:C₂₄H₂₁F₂NO₆S
Molecular Weight:489.497
Hs Code.:

Synonyms:4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

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Technology Process of 4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

There total 9 articles about 4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1345879-50-6
4-(4-(difluoromethoxy)-2-hydroxy-3-methoxyphenyl)-2,3-dihydro-1H-inden-1-one

: 40724-47-8
4-bromomethyl-benzenesulfonamide

: 1345879-58-4
4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 16h;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1345879-58-4
4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

3: hydrogenchloride; water / methanol / 1 h / 50 °C

4: potassium carbonate / acetonitrile / 16 h / 80 °C

With hydrogenchloride; water; potassium acetate; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 87-66-1
2-hydroxyresorcinol

: 1345879-58-4
4-[3-difluoromethoxy-2-methoxy-6-(1-oxoindan-4-yl)phenoxymethyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydrogencarbonate / acetone / 16 h / Reflux

2: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

3: potassium carbonate / acetone / 7 h / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

6: hydrogenchloride; water / methanol / 1 h / 50 °C

7: potassium carbonate / acetonitrile / 16 h / 80 °C

With hydrogenchloride; N-Bromosuccinimide; water; potassium carbonate; potassium hydrogencarbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; acetonitrile;