5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

Base Information

Chemical Name:5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide
CAS No.:179072-17-4
Molecular Formula:C₂₅H₃₀N₂O₂SSi
Molecular Weight:450.677
Hs Code.:

Synonyms:5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

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Chemical Property of 5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

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Technology Process of 5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

There total 8 articles about 5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179072-16-3
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinic acid methyl ester

: 179072-17-4
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

Guidance literature:: With ammonia; In methanol; Ambient temperature;
DOI:10.1080/07328319608007388

Reference yield:

: 37669-64-0
(5-bromopyridin-3-yl)methanol

: 179072-17-4
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

2: 1.) BuLi / 1.) THF, -78 deg C, 5 min

3: 50 percent / tetrahydrofuran; diethyl ether

4: 90 percent / NH₄F / methanol / 3 h / 60 °C

5: 1.) HCl, 2.) SOCl₂ / 1.) CH₂Cl₂, 5 min, 2.) reflux, 2 h

6: 84 percent / Na / dimethylformamide / Ambient temperature

7: 70 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

8: NH₃ / methanol / Ambient temperature

With 1H-imidazole; hydrogenchloride; ammonium fluoride; n-butyllithium; thionyl chloride; ammonia; sodium; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1080/07328319608007388

Reference yield:

: 129747-52-0
methyl 5-(hydroxymethyl)pyridine-3-carboxylate

: 179072-17-4
5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethylsulfanylmethyl]-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) HCl, 2.) SOCl₂ / 1.) CH₂Cl₂, 5 min, 2.) reflux, 2 h

2: 84 percent / Na / dimethylformamide / Ambient temperature

3: 70 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

4: NH₃ / methanol / Ambient temperature

With 1H-imidazole; hydrogenchloride; thionyl chloride; ammonia; sodium; In methanol; N,N-dimethyl-formamide;
DOI:10.1080/07328319608007388