3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol

Base Information

• Chemical Name: 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol
• CAS No.: 249915-81-9
• Molecular Formula: C₂₃H₁₄Br₂F₃NO₂
• Molecular Weight: 553.173
• Mol file: 249915-81-9.mol

Synonyms:3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol

Chemical Property of 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol

There total 7 articles about 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4'-(2-benzyl-benzo[b]thiophen-3-yl)-biphenyl-4-ol (250279-17-5) → 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol (249915-81-9)

Guidance literature:

With bromine; potassium acetate; acetic acid; at 5 ℃; for 0.5h;

Reference yield:

4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-4-yl]-biphenyl-4-ol (249915-75-1) → 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol (249915-81-9)

Guidance literature:

With bromine; potassium acetate; In acetic acid;

DOI:10.1021/jm990560c

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → 3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol (249915-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / Pd(PPh₃)4; Na₂CO₃ / toluene / 12 h / Heating

2: BBr₃ / CH₂Cl₂

3: Br₂; KOAc / acetic acid

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium acetate; boron tribromide; sodium carbonate; In dichloromethane; acetic acid; toluene; 1: Substitution / 2: demethylation / 3: Bromination;

DOI:10.1021/jm990560c

upstream raw materials:

4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole-4-yl]-biphenyl-4-ol

4-methoxyphenylboronic acid

4-trifluoromethyl-phenyl acetyl chloride

1-(4-bromo-phenyl)-propanone oxime

Downstream raw materials:

{3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-acetic acid methyl ester

2-{3,5-dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-3-phenyl-propionic acid methyl ester