N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide

Base Information

• Chemical Name: N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide
• CAS No.: 1370472-29-9
• Molecular Formula: C₁₈H₂₆Cl₂N₂O₂
• Molecular Weight: 373.323
• Mol file: 1370472-29-9.mol

Synonyms:N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide

Chemical Property of N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide

There total 1 articles about N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + 2-chloro-benzaldehyde (89-98-5) + N-butylamine (109-73-9,85404-21-3) + chloroacetic acid (79-11-8) → N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide (1370472-29-9)

Guidance literature:

2-chloro-benzaldehyde; N-butylamine; In dichloromethane; at 20 ℃; for 0.333333h;

tert-butylisonitrile; chloroacetic acid; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1002/hlca.201300057

Reference yield: 84.0%

N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide (1370472-29-9) → 2-azido-N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-acetamide (1370471-40-1)

Guidance literature:

With sodium azide; potassium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2013.11.002

Reference yield:

N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-chloroacetamide (1370472-29-9) → C31H34ClN5O6 (1370471-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; potassium carbonate / ISOPROPYLAMIDE / 4 h / 20 °C

2: copper(II) sulfate pentahydrate; sodium L-ascorbate / water; dimethyl sulfoxide; tert-butyl alcohol / 12 h / 20 °C

With sodium azide; copper(II) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In ISOPROPYLAMIDE; water; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2012.01.111

upstream raw materials:

tert-butylisonitrile

2-chloro-benzaldehyde

N-butylamine

chloroacetic acid

Downstream raw materials:

2-azido-N-butyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-acetamide

C₃₁H₃₄ClN₅O₆