rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Base Information

Chemical Name:rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone
CAS No.:1450633-67-6
Molecular Formula:C₁₇H₂₀FN₃OS
Molecular Weight:333.43
Hs Code.:

Synonyms:rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

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Chemical Property of rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

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Technology Process of rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

There total 6 articles about rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450634-39-5
tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

: 1450633-67-6
rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 561297-96-9
((5-fluoro-pyridin-2-yl)-methyl)-amine

: 1450633-67-6
rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 20 °C

2: acetone / 80 °C / Sealed tube

3: sodium tetrahydroborate / methanol / 1.33 h / 0 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

6: trifluoroacetic acid / dichloromethane

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1450633-63-2
tert-butyl(5-fluoropyridin-2-yl)methylcarbamate

: 1450633-67-6
rac-(2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 80 °C / Sealed tube

2: sodium tetrahydroborate / methanol / 1.33 h / 0 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: trifluoroacetic acid / dichloromethane

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;