tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate
CAS No.:1450634-39-5
Molecular Formula:C₂₂H₂₈FN₃O₃S
Molecular Weight:433.547
Hs Code.:

Synonyms:tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

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Chemical Property of tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

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Technology Process of tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

There total 6 articles about tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450633-66-5
tert-butyl(5-fluoropiperidin-2-yl)methylcarbamate

: 13743-09-4
2-methyl-5-phenyl-1,3-thiazole-4-carboxylic acid

: 1450634-39-5
tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 561297-96-9
((5-fluoro-pyridin-2-yl)-methyl)-amine

: 1450634-39-5
tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 20 °C

2: acetone / 80 °C / Sealed tube

3: sodium tetrahydroborate / methanol / 1.33 h / 0 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1450633-65-4
tert-butyl(1-benzyl-5-fluoro-1,2,3,4-tetrahydropyridin-2-yl)methylcarbamate

: 1450634-39-5
tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide;