N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate
CAS No.:1092391-38-2
Molecular Formula:C₇H₈O₃S*C₂₃H₂₂N₆O₃
Molecular Weight:602.671
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

There total 9 articles about N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1092391-35-9
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

: 104-15-4
toluene-4-sulfonic acid

: 1092391-38-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

Guidance literature:: In ethanol; ethyl acetate; at 0 - 20 ℃; for 50h;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1092391-38-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

3.1: pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: pyridine / 15 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5.2: 15 h / 20 °C

6.1: dichloromethane / 2.5 h / 20 °C

7.1: sodium hydroxide; ethanol; water / 2 h / 40 °C

8.1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

9.1: ethanol; ethyl acetate / 50 h / 0 - 20 °C

With pyridine; sodium hydroxide; ethanol; water; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1092393-84-4
2-nitro-5-(3-nitrophenoxy)pyridine

: 1092391-38-2
N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide p-toluenesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C

2.1: pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: pyridine / 15 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

4.2: 15 h / 20 °C

5.1: dichloromethane / 2.5 h / 20 °C

6.1: sodium hydroxide; ethanol; water / 2 h / 40 °C

7.1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

8.1: ethanol; ethyl acetate / 50 h / 0 - 20 °C

With pyridine; sodium hydroxide; ethanol; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;