C₂₁H₂₇N₃O₄

Base Information

Chemical Name:C₂₁H₂₇N₃O₄
CAS No.:1425940-88-0
Molecular Formula:C₂₁H₂₇N₃O₄
Molecular Weight:385.463
Hs Code.:

C<sub>21</sub>H<sub>27</sub>N<sub>3</sub>O<sub>4</sub>

Synonyms:C₂₁H₂₇N₃O₄

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Chemical Property of C₂₁H₂₇N₃O₄

Chemical Property:

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Technology Process of C₂₁H₂₇N₃O₄

There total 8 articles about C₂₁H₂₇N₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425940-86-8
C₂₁H₂₉N₃O₅

: 1425940-88-0
C₂₁H₂₇N₃O₄

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/ol4002762

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1425940-88-0
C₂₁H₂₇N₃O₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 5 h / 20 °C / Cooling with ice

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 3102.97 Torr

3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

3.2: 8 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

6.1: lithium hydroxide monohydrate / methanol; water / 4 h / 0 - 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 20 °C

With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/ol4002762

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 1425940-88-0
C₂₁H₂₇N₃O₄

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

2.1: triethylamine / dichloromethane / 5 h / 20 °C / Cooling with ice

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 3102.97 Torr

4.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

4.2: 8 h / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C

7.1: lithium hydroxide monohydrate / methanol; water / 4 h / 0 - 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 20 °C

With oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/ol4002762