Technology Process of H-Cys(BzlOMe)-Gly3-Cys(BzlOMe)-Gly2-NH2*HBr
There total 6 articles about H-Cys(BzlOMe)-Gly3-Cys(BzlOMe)-Gly2-NH2*HBr which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
In
acetic acid;
for 0.666667h;
Ambient temperature;
DOI:10.1039/P19810000310
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / N,N'-dicyclohexylcarbodi-imide / ethyl acetate / 1.) 0 deg C, 1-2 h, 2.) room temperature, overnight
2: 85 percent / 1 M NaHCO3 / dioxane; H2O / 24 h / Ambient temperature
3: 1.) Et3N, isobutyl chloroformate / 1.) DMF, -15 deg C, 15 min, 2.) -10 deg C, 1 h, room temperature, overnight
4: 95 percent / 22.5percent hydrogen bromide / acetic acid / 0.67 h / Ambient temperature
With
hydrogen bromide; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate;
In
1,4-dioxane; water; acetic acid; ethyl acetate;
DOI:10.1039/P19810000310
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 85 percent / 1 M NaHCO3 / dioxane; H2O / 24 h / Ambient temperature
2: 1.) Et3N, isobutyl chloroformate / 1.) DMF, -15 deg C, 15 min, 2.) -10 deg C, 1 h, room temperature, overnight
3: 95 percent / 22.5percent hydrogen bromide / acetic acid / 0.67 h / Ambient temperature
With
hydrogen bromide; sodium hydrogencarbonate; triethylamine; isobutyl chloroformate;
In
1,4-dioxane; water; acetic acid;
DOI:10.1039/P19810000310
