3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

Base Information

Chemical Name:3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide
CAS No.:1338792-40-7
Molecular Formula:C₂₁H₂₀N₄O₄S₂
Molecular Weight:456.546
Hs Code.:

Synonyms:3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

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Chemical Property of 3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

Chemical Property:

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Technology Process of 3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

There total 6 articles about 3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(5-amino-1H-indazol-3-yl)benzenesulfonamide 2,2,2-trifluoroacetate

: 53531-68-3
(3-methylphenyl)methanesulfonyl chloride

: 1338792-40-7
3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

Guidance literature:: 3-(5-amino-1H-indazol-3-yl)benzenesulfonamide 2,2,2-trifluoroacetate; (3-methylphenyl)methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With methylamine; In methanol; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2014.06.027

Reference yield:

: 19335-11-6
1H-indazol-5-ylamine

: 1338792-40-7
3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate; iodine / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / water; N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: dichloromethane / 3 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

5.2: 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.06.027

Reference yield:

: 917474-59-0
(1H-indazol-5-yl)-carbamic acid tert-butyl ester

: 1338792-40-7
3-{5-[(m-tolylmethylsulfonyl)amino]-1H-indazol-3-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; iodine / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / water; N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.1: dichloromethane / 3 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

4.2: 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.06.027