tert-Butyl 1H-indazol-5-ylcarbamate

Base Information

Chemical Name:tert-Butyl 1H-indazol-5-ylcarbamate
CAS No.:917474-59-0
Molecular Formula:C₁₂H₁₅N₃O₂
Molecular Weight:233.27
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50575617
Nikkaji Number:J2.388.181K
Wikidata:Q82465021
Mol file:917474-59-0.mol

Synonyms:917474-59-0;tert-Butyl 1H-indazol-5-ylcarbamate;Tert-butyl N-(1H-indazol-5-yl)carbamate;tert-butyl (1H-indazol-5-yl)carbamate;Carbamic acid, N-1H-indazol-5-yl-, 1,1-dimethylethyl ester;SCHEMBL625972;SCHEMBL16845655;DTXSID50575617;JOQUOZJHOLTJMC-UHFFFAOYSA-N;t-butyl 1H-indazol-5-ylcarbamate;tert-Butyl1H-indazol-5-ylcarbamate;AKOS014476235;J-516762;Carbamicacid,N-1H-indazol-5-yl-,1,1-dimethylethyl ester

Suppliers and Price of tert-Butyl 1H-indazol-5-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl1H-indazol-5-ylcarbamate 95+%
5g
$ 671.00

Chemenu
tert-butyl(1H-indazol-5-yl)carbamate 95%
5g
$ 634.00

American Custom Chemicals Corporation
5-BOC-AMINOINDAZOLE 95.00%
5MG
$ 505.53

Alichem
tert-Butyl1H-indazol-5-ylcarbamate
1g
$ 400.00

Total 7 raw suppliers

Chemical Property of tert-Butyl 1H-indazol-5-ylcarbamate

Chemical Property:

Vapor Pressure:2.69E-05mmHg at 25°C
Boiling Point:357.7oC at 760 mmHg
Flash Point:170.1oC
PSA：67.01000
Density:1.267g/cm3
LogP:2.98290
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:233.116426730
Heavy Atom Count:17
Complexity:288

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl1H-indazol-5-ylcarbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=CC2=C(C=C1)NN=C2

Technology Process of tert-Butyl 1H-indazol-5-ylcarbamate

There total 2 articles about tert-Butyl 1H-indazol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 19335-11-6
1H-indazol-5-ylamine

: 917474-59-0
(1H-indazol-5-yl)-carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃; for 24h;

Reference yield: 95.0%

: 5-tert-butoxycarbonylamino-indazole-1-carboxylic acid tert-butyl ester

: 917474-59-0
(1H-indazol-5-yl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 24h;
DOI:10.1016/j.tetlet.2006.09.129

Reference yield:

: 917474-59-0
(1H-indazol-5-yl)-carbamic acid tert-butyl ester

: 1338792-75-8
3-methyl-2-phenyl-N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; iodine / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / water; N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: dichloromethane / 3 h / 0 - 20 °C

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.06.027