2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

Base Information

Chemical Name:2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester
CAS No.:155220-11-4
Molecular Formula:C₁₈H₂₂N₂O₄
Molecular Weight:330.384
Hs Code.:

Synonyms:2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

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Chemical Property of 2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

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Technology Process of 2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

There total 6 articles about 2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 155219-97-9
α-acetoxy-1-(allyloxycarbonyl)-2-benzyl-2-(2-<(trimethylsilyl)methyl>-2-propenyl)hydrazineacetic acid methyl ester

: 155220-11-4
2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

Guidance literature:: With diethylaluminium chloride; In dichloromethane; 1.) -78 deg C, 15 min, 2.) r.t.;
DOI:10.1016/S0040-4020(01)96267-2

Reference yield:

: 100-52-7
benzaldehyde

: 155220-11-4
2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / toluene / 18 h / Ambient temperature

2: 99 percent / pTSA, NaBH₃CN / tetrahydrofuran / 3.5 h / Ambient temperature

3: 58 percent / K₂CO₃, LiI / butan-2-one / 18 h / Heating

4: toluene / 18 h

5: pyridine / DMAP / 18 h / Ambient temperature

6: 83 percent / Et₂AlCl / CH₂Cl₂ / 1.) -78 deg C, 15 min, 2.) r.t.

With pyridine; diethylaluminium chloride; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; lithium iodide; dmap; In tetrahydrofuran; dichloromethane; toluene; butanone;
DOI:10.1016/S0040-4020(01)96267-2

Reference yield:

: N'-[1-Phenyl-meth-(E)-ylidene]-hydrazinecarboxylic acid allyl ester

: 155220-11-4
2-(allyloxycarbonyl)-1-benzyl-5-methylenehexahydro-3-pyridazinecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / pTSA, NaBH₃CN / tetrahydrofuran / 3.5 h / Ambient temperature

2: 58 percent / K₂CO₃, LiI / butan-2-one / 18 h / Heating

3: toluene / 18 h

4: pyridine / DMAP / 18 h / Ambient temperature

5: 83 percent / Et₂AlCl / CH₂Cl₂ / 1.) -78 deg C, 15 min, 2.) r.t.

With pyridine; diethylaluminium chloride; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; lithium iodide; dmap; In tetrahydrofuran; dichloromethane; toluene; butanone;
DOI:10.1016/S0040-4020(01)96267-2