4-aminomethyl-N¹-nitrobenzenesulfonamide

Base Information

• Chemical Name: 4-aminomethyl-N¹-nitrobenzenesulfonamide
• CAS No.: 948054-25-9
• Molecular Formula: C₇H₉N₃O₄S
• Molecular Weight: 231.232
• Mol file: 948054-25-9.mol

Synonyms:4-aminomethyl-N¹-nitrobenzenesulfonamide

Chemical Property of 4-aminomethyl-N¹-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-aminomethyl-N¹-nitrobenzenesulfonamide

There total 4 articles about 4-aminomethyl-N¹-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

mafenide hydrochloride (138-37-4) → 4-aminomethyl-N1-nitrobenzenesulfonamide (948054-25-9)

Guidance literature:

With ammonium nitrate; sulfuric acid; In water; at 0 ℃; for 0.25h;

DOI:10.1016/j.bmc.2016.05.072

Reference yield:

4-homosulfanilamide (138-39-6) → 4-aminomethyl-N1-nitrobenzenesulfonamide (948054-25-9)

Guidance literature:

With ammonium nitrate; sulfuric acid; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.8b00430

Reference yield:

4-homosulfanilamide (138-39-6) → 4-aminomethyl-N1-nitrobenzenesulfonamide (948054-25-9) + 4-(aminomethyl)benzenesulfonic acid (2393-24-0)

Guidance literature:

With ammonium nitrate; sulfuric acid; at 0 - 5 ℃; for 0.25h; Title compound not separated from byproducts.;

DOI:10.1055/s-2007-983715

upstream raw materials:

4-homosulfanilamide

mafenide hydrochloride

Downstream raw materials:

4-(aminomethyl)benzenesulfonic acid

Refernces

• 1、 Nocentini, Alessio,Vullo, Daniela,Bartolucci, Gianluca,Supuran, Claudiu T.. "N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition". . p. 3612 - 3617. Retrieved 2016/07/20.