(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

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Chemical Name:(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride
CAS No.:1443752-79-1
Molecular Formula:C₂₉H₃₁NO₄*ClH
Molecular Weight:494.03
Hs Code.:

Synonyms:(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

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Chemical Property of (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

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Technology Process of (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

There total 21 articles about (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443752-76-8
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol

: 1443752-79-1
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 0.25h;

Reference yield:

: 17720-60-4,423150-69-0
2,4,4'-trihydroxy deoxybenzoin

: 1443752-79-1
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / 0.75 h / -10 - 0 °C

2: piperidine / toluene / 24 h / Reflux

3: tetrahydrofuran / 6 h / 0 - 20 °C

4: acetic acid; water / 2 h / 90 °C

5: Diacel, Chiralpak IC / hexane; isopropyl alcohol / Resolution of racemate

6: hydrogenchloride / methanol / 0.25 h

With piperidine; hydrogenchloride; water; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; hexane; isopropyl alcohol; toluene;

Reference yield:

: 108-46-3
recorcinol

: 1443752-79-1
(2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: boron trifluoride diethyl etherate / toluene / 1.5 h / 100 - 108 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 0.75 h / -10 - 0 °C

3: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / iso-butanol / 50 - 130 °C / Dean-Stark

4: tetrahydrofuran / 1.5 h / 5 - 20 °C

5: acetic acid; water / 1.5 h / 90 °C / Inert atmosphere

6: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

7: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / 91 h / 120 °C / Inert atmosphere

8: acetic acid; water / 1 h / 90 °C

9: Diacel, Chiralpak IC / hexane; isopropyl alcohol / Resolution of racemate

10: hydrogenchloride / methanol / 0.25 h

With piperidine; hydrogenchloride; copper(l) iodide; 1,10-Phenanthroline; boron trifluoride diethyl etherate; water; pyridinium p-toluenesulfonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; toluene; iso-butanol;