(4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

Base Information

Chemical Name:(4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one
CAS No.:116627-67-9
Molecular Formula:C₂₂H₂₇IO₃Si
Molecular Weight:494.445
Hs Code.:

(4R,6S)-trans-4-<t-butyl(diphenyl)silyloxy>-6-iodomethyltetrahydropyran-2-one

Synonyms:(4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

Chemical Property:

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Technology Process of (4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

There total 14 articles about (4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 927211-53-8
(4R,6S)-4-tert-butyldiphenylsilyloxy-6-(p-tosyloxymethyl)tetrahydropyran-2-one

: 116627-67-9
(4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

Guidance literature:: With sodium iodide; In acetone; Heating;
DOI:10.1016/S0040-4039(00)86112-2

Reference yield:

: 121772-46-1
(3R)-3-hex-5-enoic acid

: 121772-47-2
(4R,6R)-cis-4--6-iodomethyltetrahydropyran-2-one

: 116627-67-9
(4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

Guidance literature:: With iodine; sodium hydrogencarbonate; In various solvent(s); at 0 ℃; for 3h;
DOI:10.1016/S0040-4039(00)80629-2

Reference yield:

: 116697-28-0
(4R,6S)-6-Benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-pyran-2-ol

: 116627-67-9
(4R,6S)-trans-4--6-iodomethyltetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / CrO₃ / pyridine; CH₂Cl₂ / 10 °C

2: 92 percent / H₂ / Pd/C

3: 80 percent / pyridine; CH₂Cl₂ / 0 °C

4: 91 percent / NaI / acetone / Heating

With chromium(VI) oxide; hydrogen; sodium iodide; palladium on activated charcoal; In pyridine; dichloromethane; acetone;
DOI:10.1016/S0040-4039(00)86112-2