6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

Base Information

Chemical Name:6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline
CAS No.:120296-53-9
Molecular Formula:C₂₄H₂₆N₂O₅S
Molecular Weight:454.547
Hs Code.:

Synonyms:6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

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Technology Process of 6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

There total 1 articles about 6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20057-83-4
diethyl 4,4'-dithiobis

: 106585-53-9
<6-(bromomethyl)-4-oxo-3(4H)-quinazolinyl>methyl 2,2-dimethylpropanoate

: 120296-53-9
6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

Guidance literature:: With sodium tetrahydroborate; Yield given. Multistep reaction; 1.) EtOH, 15 min, 2.) DMF, r.t., 2 h;
DOI:10.1021/jm00127a026

Reference yield: 89.0%

: 120296-53-9
6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

: 120296-54-0
6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-quinazoline

Guidance literature:: With sodium hydroxide; In ethanol; for 42h; Ambient temperature;
DOI:10.1021/jm00127a026

Reference yield:

: 120296-53-9
6-<<(4-Carbethoxyphenyl)thio>methyl>-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>quinazoline

: 120296-43-7
N^a-(2-Desamino-10-thia-5,8-dideazapteroyl)-L-ornithine

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 1 a.) 1 N NaOH / ethanol / 42 h / Ambient temperature

2: 1.) Et₃N, diethyl phosphorocyanidate / 1.) DMF, 1.5 h, 2.) DMF, 3 h

3: 74 percent / CF₃COOH / 2 h

With sodium hydroxide; diethyl cyanophosphonate; triethylamine; trifluoroacetic acid; In ethanol;
DOI:10.1021/jm00127a026