20057-83-4Relevant academic research and scientific papers
Synthesis of Functionalized Diaryl Sulfides by Cobalt-Catalyzed Coupling between Arylzinc Pivalates and Diaryl Disulfides
Dong, Zhi-Bing,Balkenhohl, Moritz,Tan, Eric,Knochel, Paul
supporting information, p. 7581 - 7584 (2018/11/27)
An efficient protocol for the cobalt-catalyzed preparation of diaryl sulfides from solid organozinc pivalates and commercially available diaryl disulfides is reported. This cross-coupling proceeds at room temperature and displays a good functional group tolerance, allowing the preparation of a diversity of symmetrical or asymmetrical diaryl sulfides in 60-95% yield.
Chemoselective synthesis of diaryl disulfides via a visible light-mediated coupling of arenediazonium tetrafluoroborates and CS2
Leng, Jing,Wang, Shi-Meng,Qin, Hua-Li
supporting information, p. 903 - 909 (2017/06/23)
A highly efficient and chemoselective method for the synthesis of diaryl disulfides is developed via a visible light-promoted coupling of readily accessible arenediazonium tetrafluoroborates and CS2. This practical and convenient protocol provides a direct pathway for the assembly of a series of disulfides in an environmentally friendly manner with good to excellent yields.
Graphene Oxide: An Efficient Acid Catalyst for the Construction of Esters from Acids and Alcohols
Chen, Zhengwang,Wen, Yuelu,Fu, Yejuan,Chen, Hai,Ye, Min,Luo, Guotian
supporting information, p. 981 - 985 (2017/05/05)
Graphene oxide was found to be an efficient and reusable acid catalyst for the esterification reaction. A wide range of aliphatic and aromatic acids and alcohols were compatible with the standard conditions and afforded the corresponding products in good yields. The heterogeneous catalyst can be easily recovered and recycled in dichloro-ethane solvent with good catalytic activity.
Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: Design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates
Gangjee, Aleem,Jain, Hiteshkumar D.,Phan, Jaclyn,Lin, Xin,Song, Xiaohong,McGuire, John J.,Kisliuk, Roy L.
, p. 1055 - 1065 (2007/10/03)
We designed and synthesized a classical analogue N-[4-[(2-amino-6-ethyl-3, 4-dihydro-4-oxo-7H-pyrrolo-[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid (4) and thirteen nonclassical analogues 5-17 as potential dual thymidylate synthase (TS) and dihydrof
A direct preparation of functionalized aryl and heteroaryl disulfides from functionalized zinc organometallics by using sulfur monochloride (S 2Cl2)
Korn, Tobias J.,Knochel, Paul
, p. 1185 - 1187 (2007/10/03)
A range of functionalized aryl and heteroaryl disulfides has been prepared from zinc organometallics by using sulfur monochloride (S2Cl 2). The zinc reagents were obtained by transmetalation from magnesium or lithium reagents with ZnBr2.
5-Arylthio-Substituted 2-Amino-4-oxo-6-methylpyrrolopyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents
Gangjee, Aleem,Devray, Rajesh,McGuire, John J.,Kisliuk, Roy L.
, p. 4495 - 4502 (2007/10/03)
Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects.In addition, these analogues are polyglutamylated via the enzyme folylpoly-γ-glutamate synthetase (FPGS),
Investigations on Benzothiirene
Meier, Herbert,Konnerth, Ursula,Graw, Sylvia,Echter, Toni
, p. 107 - 126 (2007/10/02)
Thermolysis and photolysis of 1,2,3-benzothiadiazole 10c furnish the products 11c - 15c. 13C-labelling experiments demonstrate that an intermediate benzothiirene 1c is not formed.Isotopomeric reaction products are due to H-shifts.Electron withdrawing ester groups in 6-position enable the ring closure to the substituted benzothiirenes 1d, e on the photochemical but not on the thermal route.A proof is given by an extensive study of the disulfides 14d, e, 14d', e', and 14d'', e'', generated in the thermolysis, photolysis and by an independent procedure.The results are based on 13C and 1H NMR measurements.Unequivocal signal correlations were made by deuterations and heteronuclear double resonances.
