Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

Base Information

Chemical Name:Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate
CAS No.:1292291-70-3
Molecular Formula:C₃₅H₃₉NO₃
Molecular Weight:521.7
Hs Code.:

Synonyms:Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

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Chemical Property of Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

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Technology Process of Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

There total 8 articles about Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

: 428-38-6
2,3-dihydrospiro[1H-indene-1,4'-piperidine]

: 1292291-01-0
Ethyl (3S)-3-[4-[[4-(bromomethyl)phenyl]methoxy]phenyl]hex-4-ynoate

: 1292291-70-3
Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1292291-70-3
Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / 2 h / 75 °C

2.1: tetrahydrofuran / 0.25 h / 50 °C / Inert atmosphere

3.1: pyridine; water / 16 h / Reflux

3.2: pH ~ 2

4.1: trifluoroacetic acid / isopropyl alcohol; hexane / Resolution of racemate

5.1: sulfuric acid / 4 h / Reflux

6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: caesium carbonate / acetonitrile / 20 °C

With pyridine; sulfuric acid; water; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 623-24-5
1,4-bis(bromomethyl)benzene

: 1292291-70-3
Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2: caesium carbonate / acetonitrile / 20 °C

With caesium carbonate; In N,N-dimethyl-formamide; acetonitrile;