O6-PHENYL-2'-DEOXYINOSINE

Base Information

• Chemical Name: O6-PHENYL-2'-DEOXYINOSINE
• CAS No.: 114485-36-8
• Molecular Formula: C16H16 N4 O4
• Molecular Weight: 328.32
• Mol file: 114485-36-8.mol

Synonyms:O6-PHENYL-2’-DEOXYINOSINE

Chemical Property of O6-PHENYL-2'-DEOXYINOSINE

Chemical Property:

• Boiling Point: 612.5±65.0 °C(Predicted)
• PKA: 13.76±0.60(Predicted)
• PSA: 102.52000
• Density: 1.57±0.1 g/cm3(Predicted)
• LogP: 1.25930

Purity/Quality:

97% ^*data from raw suppliers

O6-PHENYL-2'-DEOXYINOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O6-PHENYL-2'-DEOXYINOSINE

There total 1 articles about O6-PHENYL-2'-DEOXYINOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloropurine-2'-deoxyriboside (4594-45-0) + phenol (108-95-2,27073-41-2) → 6-(2-deoxy-β-D-erythro-pentofuranosyl)-6-phenoxypurine (114485-36-8)

Guidance literature:

With triethylamine; trimethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002032

Reference yield: 80.0%

bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate + 6-(2-deoxy-β-D-erythro-pentofuranosyl)-6-phenoxypurine (114485-36-8) → 5'-O-(4,4'-dimethoxytrityl)-O6-phenyl-2'-deoxyinosine (133471-08-6)

Guidance literature:

With 2,6-dimethylpyridine; lithium carbonate; In tetrahydrofuran; Ambient temperature;

DOI:10.1080/07328319608002032

Reference yield: 79.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 6-(2-deoxy-β-D-erythro-pentofuranosyl)-6-phenoxypurine (114485-36-8) → 5'-O-(4,4'-dimethoxytrityl)-O6-phenyl-2'-deoxyinosine (133471-08-6)

Guidance literature:

With pyridine; dmap; for 16h; Ambient temperature;

DOI:10.1021/ja00073a016

upstream raw materials:

6-chloropurine-2'-deoxyriboside

phenol

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-O⁶-phenyl-2'-deoxyinosine

D-Ribose

5'-O-(4,4'-dimethoxytrityl)-O⁶-phenyl-2'-deoxyinosine 3'-(2-cyanoethyl-N,N-diisopropyl) phosphoramidite