1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate
• CAS No.: 923009-79-4
• Molecular Formula: C₂₂H₃₁NO₆
• Molecular Weight: 405.491
• Mol file: 923009-79-4.mol

Synonyms:1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate

Chemical Property of 1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate

There total 2 articles about 1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) + Benzyl bromoacetate (5437-45-6) → 1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate (923009-79-4)

Guidance literature:

ethyl N-(t-butyloxycarbonyl)nipecotate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

Benzyl bromoacetate; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.04.047

Reference yield: 78.0%

→ 1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate (923009-79-4)

Guidance literature:

Reference yield:

1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate (923009-79-4) → C17H23NO4

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2012.04.047

upstream raw materials:

ethyl N-(t-butyloxycarbonyl)nipecotate

Benzyl bromoacetate

Downstream raw materials:

1'-tert-butyl (3S)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

1'-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate