1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

Base Information

Chemical Name:1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate
CAS No.:1380610-22-9
Molecular Formula:C₂₇H₄₀N₂O₆
Molecular Weight:488.624
Hs Code.:

Synonyms:1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

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Chemical Property of 1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

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Technology Process of 1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

There total 5 articles about 1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1042441-53-1,1042441-54-2,923011-24-9
1'-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

: 1380610-25-2
1'-tert-butyl (3S)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

: 1380610-22-9
1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

Guidance literature:: With CHIRALPAK AD-H; In ethanol; hexane; at 35 ℃; Purification / work up; Resolution of racemate;

Reference yield:

: 923009-79-4
1-tert-butyl 3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]piperidine-1,3-dicarboxylate

: 1380610-25-2
1'-tert-butyl (3S)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

: 1380610-22-9
1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 0.5 h / 20 °C

2: sodium tris(acetoxy)borohydride; triethylamine / tetrahydrofuran; acetic acid / 16 h / 20 °C

3: CHIRALPAK AD / ethanol; hexane / 35 °C / Resolution of racemate

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; ethanol; hexane; acetic acid; ethyl acetate;
DOI:10.1016/j.bmcl.2012.04.047

Reference yield:

: C₁₇H₂₃NO₄

: 1380610-25-2
1'-tert-butyl (3S)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

: 1380610-22-9
1'-tert-Butyl (3R)-3-ethyl 3-[2-(benzyloxy)-2-oxoethyl]-1,4'-bipiperidine-1',3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; triethylamine / tetrahydrofuran; acetic acid / 16 h / 20 °C

2: CHIRALPAK AD / ethanol; hexane / 35 °C / Resolution of racemate

With sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; ethanol; hexane; acetic acid;
DOI:10.1016/j.bmcl.2012.04.047