N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

Base Information

Chemical Name:N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide
CAS No.:1430330-82-7
Molecular Formula:C₃₃H₂₉ClN₆O₄S
Molecular Weight:641.15
Hs Code.:

Synonyms:N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

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Chemical Property of N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

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Technology Process of N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

There total 10 articles about N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1430331-47-7
2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

: 1430330-82-7
N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 72h;

Reference yield:

: 1430331-39-7
2-(4-chlorophenylamino)benzo[d]oxazol-5-ol

: 1430330-82-7
N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 - 90 °C

2: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 - 50 °C

3: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 7 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

6: water; sodium hydroxide / methanol / 72 h / 20 °C

With hydrogenchloride; potassium tert-butylate; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1430331-41-1
5-(2-(5-(1,3-dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-N-(4-chlorophenyl)benzo[d]oxazol-2-amine

: 1430330-82-7
N-(1-((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-yl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 - 50 °C

2: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 7 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

5: water; sodium hydroxide / methanol / 72 h / 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide;