2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

Base Information

Chemical Name:2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate
CAS No.:1430331-47-7
Molecular Formula:C₃₅H₃₁ClN₆O₅S
Molecular Weight:683.187
Hs Code.:

Synonyms:2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

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Chemical Property of 2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

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Technology Process of 2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

There total 9 articles about 2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 13831-30-6
acetoxyacetic acid

: 1430331-45-5
5-(2-(5-((4-aminopiperidin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-N-(4-chlorophenyl)benzo[d]oxazol-2-amine

: 1430331-47-7
2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1430331-39-7
2-(4-chlorophenylamino)benzo[d]oxazol-5-ol

: 1430331-47-7
2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 - 90 °C

2: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 - 50 °C

3: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

4: hydrogenchloride / dichloromethane; 1,4-dioxane / 7 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; potassium tert-butylate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1430331-41-1
5-(2-(5-(1,3-dioxolan-2-yl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-N-(4-chlorophenyl)benzo[d]oxazol-2-amine

: 1430331-47-7
2-(((6-(7-(2-(4-chlorophenylamino)benzo[d]oxazol-5-yloxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperidin-4-ylamino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 - 50 °C

2: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane / 7 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;