(R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane

Base Information

• Chemical Name: (R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane
• CAS No.: 114446-47-8
• Molecular Formula: C16H17 Cl O
• Molecular Weight: 260.763
• Mol file: 114446-47-8.mol

Synonyms:Benzene,1-(3-chloro-1-phenylpropoxy)-2-methyl-, (R)-

Chemical Property of (R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 375.403°C at 760 mmHg
• Flash Point: 179.533°C
• PSA: 9.23000
• Density: 1.107g/cm³
• LogP: 4.74400
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

(R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A chiral intermediate of Desmethyl atomoxetine A chiral intermediate of Desmethyl atomoxetine.

Technology Process of (R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane

There total 9 articles about (R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

2-Fluorotoluene (95-52-3) + (1R)-3-chloro-1-phenylpropanol (100306-33-0,125712-82-5) → -(-)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane (114446-47-8)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃; Temperature;

Reference yield: 75.0%

3-chloro-1-phenylpropanol (100306-34-1,125712-82-5) + ortho-cresol (95-48-7,77504-84-8) → -(-)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane (114446-47-8)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2004.11.052

Reference yield: 70.0%

azodicarboxylic acid ethyl ester + 3-chloro-1-phenylpropanol (100306-34-1,125712-82-5) + ortho-cresol (95-48-7,77504-84-8) → -(-)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane (114446-47-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; pentane;

upstream raw materials:

3-chloro-1-phenylpropanol

ortho-cresol

3-chloropropiophenone

3-chloro-1-phenyl-propan-1-ol

Downstream raw materials:

atomoxetine hydrochloride

(R)-tomoxetine