2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

Base Information

Chemical Name:2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide
CAS No.:1285515-37-8
Molecular Formula:C₂₄H₂₃F₂N₃O₃
Molecular Weight:439.462
Hs Code.:

Synonyms:2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

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Chemical Property of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

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Technology Process of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

There total 5 articles about 2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1285514-75-1
2-{[(3,4-difluorophenyl)methyl]oxy}-5-formyl-N-3-pyridinylbenzamide

: 1285515-37-8
2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

Guidance literature:: morpholine; 2-{[(3,4-difluorophenyl)methyl]oxy}-5-formyl-N-3-pyridinylbenzamide; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 50 ℃;

With sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane; for 0.166667h;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285515-37-8
2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C

2.2: 50 °C

2.3: 0.17 h

With N-ethylmorpholine;; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285515-37-8
2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2.2: pH 1

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C

4.2: 50 °C

4.3: 0.17 h

With N-ethylmorpholine;; water; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;