Technology Process of N-((1S,2S,3R,4S,5S)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2,5-dihydroxy-cyclohexyl)-4-methyl-benzenesulfonamide
There total 7 articles about N-((1S,2S,3R,4S,5S)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2,5-dihydroxy-cyclohexyl)-4-methyl-benzenesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; triethylbutylammonium chloride;
In
chloroform; water; tert-butyl alcohol;
at 50 ℃;
for 16h;
DOI:10.1016/S0040-4039(98)02539-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / BuLi / tetrahydrofuran / 0 - 20 °C
2: 87 percent / CrO3, pyridine / CH2Cl2 / 0 deg C, 30 min then rt., 16 h
3: 97 percent / tetrahydrofuran / 16 h / -78 - 20 °C
4: 82 percent / 2,6-lutidine / 16 h / Ambient temperature
5: 42 percent / PhMe2CCH=Mo=N<2,6-(i-Pr)2C6H3>3)2>2 / benzene / 16 h / Ambient temperature
6: 92 percent / Bu4N(1+)*F(1-) / tetrahydrofuran / 16 h / -20 - 0 °C
7: 55 percent / OsO4, Et3BuN(1+)*Cl(1-) / 2-methyl-propan-2-ol; CHCl3; H2O / 16 h / 50 °C
With
pyridine; 2,6-dimethylpyridine; chromium(VI) oxide; osmium(VIII) oxide; n-butyllithium; tetrabutyl ammonium fluoride; triethylbutylammonium chloride;
bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum;
In
tetrahydrofuran; dichloromethane; chloroform; water; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(98)02539-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 97 percent / tetrahydrofuran / 16 h / -78 - 20 °C
2: 82 percent / 2,6-lutidine / 16 h / Ambient temperature
3: 42 percent / PhMe2CCH=Mo=N<2,6-(i-Pr)2C6H3>3)2>2 / benzene / 16 h / Ambient temperature
4: 92 percent / Bu4N(1+)*F(1-) / tetrahydrofuran / 16 h / -20 - 0 °C
5: 55 percent / OsO4, Et3BuN(1+)*Cl(1-) / 2-methyl-propan-2-ol; CHCl3; H2O / 16 h / 50 °C
With
2,6-dimethylpyridine; osmium(VIII) oxide; tetrabutyl ammonium fluoride; triethylbutylammonium chloride;
bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum;
In
tetrahydrofuran; chloroform; water; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(98)02539-8
