3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}

Base Information

• Chemical Name: 3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}
• CAS No.: 1228649-83-9
• Molecular Formula: C₄₅H₄₉N₄O₁₂P
• Molecular Weight: 868.877

Synonyms:3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}

Chemical Property of 3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}

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Technology Process of 3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}

There total 2 articles about 3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

L-Alanine methyl ester (10065-72-2) + 3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine (1171006-90-8) + diphenyl hydrogen phosphite (4712-55-4) → 3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate} (1228649-83-9)

Guidance literature:

3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine; diphenyl hydrogen phosphite; In pyridine; for 0.5h; Inert atmosphere;

L-Alanine methyl ester; With tetrachloromethane; triethylamine; In pyridine; acetonitrile; for 1.16667h;

Reference yield:

L-Alanine methyl ester (10065-72-2) + C41H42N3O10P → 3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate} (1228649-83-9)

Guidance literature:

With pyridine; triethylamine; In tetrachloromethane; acetonitrile; for 1.16667h;

DOI:10.1039/b924321f

Reference yield: 50.0%

3'-O-levulinoyl-N(4)-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate} (1228649-83-9) → 2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate} (1228649-74-8)

Guidance literature:

3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}; With hydrazine hydrate; acetic acid; In pyridine; for 5h;

With water; acetic acid; at 55 - 65 ℃; for 6.5h;

upstream raw materials:

L-Alanine methyl ester

3'-O-levulinoyl-N⁽⁴⁾-(4-methoxytrityl)-2'-O-methylcytidine

diphenyl hydrogen phosphite

Downstream raw materials:

2'-O-methylcytidine 5'-{O-phenyl-N-[(S)-2-methoxy-1-methyl-2-oxoethyl]phosphoramidate}

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