8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

Base Information

Chemical Name:8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine
CAS No.:1053261-67-8
Molecular Formula:C₂₉H₄₆N₆O₅Si₂
Molecular Weight:614.892
Hs Code.:

Synonyms:8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

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Chemical Property of 8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

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Technology Process of 8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

There total 3 articles about 8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1053718-26-5
8-bromo-3',5'-O-tetrakisisopropyldisiloxanediyl-2'-deoxyadenosine

: 104-94-9
4-methoxy-aniline

: 1053261-67-8
8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; Reflux;
DOI:10.1002/chem.200800979

Reference yield:

: 14985-44-5,90968-89-1
8-bromo-2'-deoxyadenosine

: 1053261-67-8
8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / 16 h / 20 °C

2: 70 percent / Cs₂CO₃; rac-BINAP / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 48 h / 90 °C

With pyridine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,2-dimethoxyethane;
DOI:10.1055/s-2006-950411

Reference yield:

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

: 1053261-67-8
8-N-(4-methoxyphenylamino)-3',5'-O-[1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl]-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / acetate buffer / 3 h / 20 °C / pH 5

2: 98 percent / pyridine / 16 h / 20 °C

3: 70 percent / Cs₂CO₃; rac-BINAP / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 48 h / 90 °C

With pyridine; bromine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,2-dimethoxyethane; acetate buffer;
DOI:10.1055/s-2006-950411