(3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one

Base Information

• Chemical Name: (3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one
• CAS No.: 72690-84-7
• Molecular Formula: C₁₅H₁₈N₂O₇
• Molecular Weight: 338.317
• Mol file: 72690-84-7.mol

Synonyms:(3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one

Chemical Property of (3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one

There total 30 articles about (3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,4R)-3-[(1RS)-1-(p-nitrobenzyloxycarbonyloxy)ethyl]-4-(2-oxoethyl)-2-oxoazetidine (64066-71-3,67314-42-5,71869-79-9,72778-03-1,77447-99-5,80559-32-6) → (3S,4R)-4-(2-hydroxyethyl)-3-[(1RS)-1-(p-nitrobenzyloxycarbonyloxy)-ethyl]-2-oxoazetidine (64066-69-9,65794-42-5,65794-47-0,71883-52-8,72690-84-7,72843-56-2,78339-97-6,122797-13-1)

Guidance literature:

With sodium borohydrid; acetic acid; In methanol; ethyl acetate; acetone;

Reference yield:

C21H26N2O7 (74819-50-4,74843-50-8,133443-87-5) → (3RS,4RS)-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>azetidin-2-one (72690-84-7)

Guidance literature:

With sulfuric acid; at 50 ℃; for 24h; Yield given;

Reference yield:

Carbonic acid (R)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester (85960-27-6) → (3S,4R)-4-(2-hydroxyethyl)-3-[(1R)-1-p-nitrobenzyloxycarbonyloxyethyl]-azetidin-2-one (64066-69-9,65794-42-5,65794-47-0,71883-52-8,72690-84-7,72843-56-2,78339-97-6,122797-13-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 12h; Yield given;

DOI:10.1016/S0040-4039(00)81369-6

upstream raw materials:

(3S,4R)-3-[(1RS)-1-(p-nitrobenzyloxycarbonyloxy)ethyl]-4-(2-oxoethyl)-2-oxoazetidine

(S)-3-Amino-5-(tert-butyl-diphenyl-silanyloxy)-2-((S)-1-hydroxy-ethyl)-pentanoic acid methyl ester

(S)-3-Amino-5-(tert-butyl-diphenyl-silanyloxy)-2-((S)-1-hydroxy-ethyl)-pentanoic acid isopropyl ester

(3S,4R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-((S)-1-hydroxy-ethyl)-azetidin-2-one

Downstream raw materials:

(5RS,6RS,8RS)-p-nitrobenzyl 3,7-dioxo-6-(1-p-nitrobenzyloxycarbonyloxyethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

p-nitrobenzyl (3RS,4RS)-4-<3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-4-yl>-3-oxobutanoate

(5RS,6RS,8RS)-p-nitrobenzyl 3-diphenylthiophosphinoyl-6-(1-p-nitrobenzyloxycarbonyloxyethyl)-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

(5RS,6RS,8RS)-p-nitrobenzyl 3-<2-(p-nitrobenzyloxycarbonylamino)ethylthio>-6-(1-p-nitrobenzyloxycarbonyloxyethyl)-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate