tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

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Chemical Name:tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate
CAS No.:1313189-61-5
Molecular Formula:C₂₅H₃₄INO₅S
Molecular Weight:587.519
Hs Code.:

Synonyms:tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

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Chemical Property of tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

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Technology Process of tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

There total 5 articles about tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1313189-60-4
tert-butyl N-methyl-N-[2-(4-{3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]carbamate

: 1313189-61-5
tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

Guidance literature:: With iodine; mercury(II) oxide; In benzene; at 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100166

Reference yield:

: 13781-67-4
3-(2-hydroxyethyl)thiophene

: 1313189-61-5
tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / chloroform; acetone / 1 h / 0 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / diethyl ether / 4 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 20 °C / Inert atmosphere

4.1: sodium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; hexane; water / 18 h / 78 °C / Inert atmosphere

5.1: iodine; mercury(II) oxide / benzene / 20 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; iodine; sodium carbonate; toluene-4-sulfonic acid; triphenylphosphine; mercury(II) oxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; chloroform; water; acetone; benzene; 4.1: Suzuki coupling;
DOI:10.1002/ejoc.201100166

Reference yield:

: C₁₁H₁₇BO₄S

: 1313189-61-5
tert-butyl N-[2-(4-{5-iodo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]thiophen-2-yl}phenoxy)ethyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; hexane; water / 18 h / 78 °C / Inert atmosphere

2: iodine; mercury(II) oxide / benzene / 20 °C / Inert atmosphere

With iodine; sodium carbonate; triphenylphosphine; mercury(II) oxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; water; benzene; 1: Suzuki coupling;
DOI:10.1002/ejoc.201100166