(S)-(-)-Felodipine

Base Information Edit

Chemical Name:(S)-(-)-Felodipine
CAS No.:119945-59-4
Molecular Formula:C18H19 Cl2 N O4
Molecular Weight:384.25
Hs Code.:
UNII:OMN899SSSZ
DSSTox Substance ID:DTXSID20348390
Nikkaji Number:J390.517I
Wikidata:Q63390497
ChEMBL ID:CHEMBL254609
Mol file:119945-59-4.mol

Synonyms:119945-59-4;(S)-(-)-Felodipine;(R)-(+)-Felodipine;(R)-Felodipine;Felodipine, (R)-;OMN899SSSZ;UNII-OMN899SSSZ;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester, (4R)-;5-O-ethyl 3-O-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Lopac-F-9677;Felodipine III;SCHEMBL54486;CHEMBL254609;DTXSID20348390;AKOS030241019;NCGC00015455-01;NCGC00015455-02;CS-0338785;A837549;EN300-18568195;J-001458;Q63390497;(4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O5-ethyl ester O3-methyl ester;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester, (4S)-;3-ethyl 5-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;3-Ethyl 5-methyl (R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;ethyl methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;O5-ethyl O3-methyl (4R)-4-[2,3-bis(chloranyl)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of (S)-(-)-Felodipine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(+)-Felodipine
10mg
$ 1190.00

Medical Isotopes, Inc.
(R)-(+)-Felodipine
1 mg
$ 900.00

American Custom Chemicals Corporation
(R)-(+)-FELODIPINE 95.00%
10MG
$ 1963.50

American Custom Chemicals Corporation
(R)-(+)-FELODIPINE 95.00%
1MG
$ 513.45

Total 4 raw suppliers

Chemical Property of (S)-(-)-Felodipine Edit

Chemical Property:

PSA：64.63000
LogP:4.29310
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:383.0691135
Heavy Atom Count:25
Complexity:614

Purity/Quality:

97% ^*data from raw suppliers

(R)-(+)-Felodipine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Isomeric SMILES:CCOC(=O)C1=C(NC(=C([C@H]1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Uses A dihydropyridine calcium channel blocker. Enantiomer R of Felodipine A dihydropyridine calcium channel blocker. Enantiomer R of Felodipine.

Technology Process of (S)-(-)-Felodipine

There total 3 articles about (S)-(-)-Felodipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127634-12-2
(S)-4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-[(R)-1-hydroxymethyl-2-(toluene-4-sulfonyl)-ethyl] ester

: 119945-59-4,86189-69-7
(R)-Felodipine

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / methanol / 2 h / Ambient temperature

2: 1.) KOH / 1.) MeOH; 2.) DMF

With potassium hydroxide; In methanol;
DOI:10.1016/S0040-4039(01)93912-7