<3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

Base Information

Chemical Name:<3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan
CAS No.:141468-40-8
Molecular Formula:C₁₆H₂₀O₄
Molecular Weight:276.332
Hs Code.:

Synonyms:<3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

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Chemical Property of <3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

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Technology Process of <3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

There total 7 articles about <3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 141468-39-5,141552-84-3
methyl 3-O-propargyl-3-C-<(benzyloxy)methyl>-2-O-<(s-methylthio)-thio-carbonyl>-D-threo-furanose

: 141468-40-8
<3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1h; Heating;
DOI:10.1016/S0040-4039(00)91668-X

Reference yield:

: 14048-35-2
(-)-(3aR,6S,6aR)-6-hydroxymethyl-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol

: 141468-40-8
<3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

Guidance literature:: Multi-step reaction with 5 steps

1: 1) (Bu₃Sn)2O, 2) Bu₄NBr / 1) toluene, reflux, 4 h, 2) 80 deg C, 12 h

2: 95 percent / NaH / dimethylformamide / 16 h / Ambient temperature

3: 92 percent / HCl / tetrahydrofuran / 48 h / Ambient temperature

4: 94 percent / NaH / dimethylformamide

5: 40 percent / Bu₃SnH, AIBN / toluene / 1 h / Heating

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; tri-n-butyl-tin hydride; sodium hydride; bis(tri-n-butyltin)oxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)91668-X

Reference yield:

: 100-39-0
benzyl bromide

: 141468-40-8
<3aS,4R,6aS>-3-methylidene-4-methoxy-6a-<(benzyloxy)methyl>perhydrofluoro-<3,4-b>furan

Guidance literature:: Multi-step reaction with 5 steps

1: 1) (Bu₃Sn)2O, 2) Bu₄NBr / 1) toluene, reflux, 4 h, 2) 80 deg C, 12 h

2: 95 percent / NaH / dimethylformamide / 16 h / Ambient temperature

3: 92 percent / HCl / tetrahydrofuran / 48 h / Ambient temperature

4: 94 percent / NaH / dimethylformamide

5: 40 percent / Bu₃SnH, AIBN / toluene / 1 h / Heating

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; tri-n-butyl-tin hydride; sodium hydride; bis(tri-n-butyltin)oxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)91668-X