3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine

Base Information

• Chemical Name: 3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine
• CAS No.: 943818-38-0
• Molecular Formula: C₃₃H₃₁NO₁₁P₂
• Molecular Weight: 679.557
• Mol file: 943818-38-0.mol

Synonyms:3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine

Chemical Property of 3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine

There total 1 articles about 3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-(tert-butoxycarbonyl)-morpholine-3,5-dione (943818-71-1) + chlorophosphoric acid diphenyl ester (2524-64-3) → 3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine (943818-38-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

DOI:10.1021/jo070528n

Reference yield: 91.0%

3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine (943818-38-0) + 1-(trimethylstannyl)-2-phenylethyne (1199-95-7) → 4-(tert-butoxycarbonyl)-3,5-bis(phenylethynyl)-4H-[1,4]oxazine (943818-41-5)

Guidance literature:

With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo070528n

Reference yield: 86.0%

3,5-bis{[bis(phenyloxy)phosphoryl]oxy}-4-(tert-butoxycarbonyl)-[1,4]oxazine (943818-38-0) + phenylboronic acid (98-80-6) → 4-(tert-butoxycarbonyl)-3,5-diphenyl-4H-[1,4]oxazine (943818-42-6)

Guidance literature:

With barium dihydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; water; for 1h; Heating;

DOI:10.1021/jo070528n

upstream raw materials:

4-(tert-butoxycarbonyl)-morpholine-3,5-dione

chlorophosphoric acid diphenyl ester

Downstream raw materials:

4-(tert-butoxycarbonyl)-3,5-bis(phenylethynyl)-4H-[1,4]oxazine

4-(tert-butoxycarbonyl)-3,5-diphenyl-4H-[1,4]oxazine

4-(tert-butoxycarbonyl)-3,5-diphenyl-2-[hydroxy-(3,4,5-trimethoxyphenyl)-methyl]-4H-[1,4]oxazine

4-(tert-butoxycarbonyl)-3,5-diphenyl-2-formyl-4H-[1,4]oxazine