(E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester

Base Information

• Chemical Name: (E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester
• CAS No.: 1169983-78-1
• Molecular Formula: C₁₆H₁₄BrNO₂
• Molecular Weight: 332.197
• Mol file: 1169983-78-1.mol

Synonyms:(E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester

Chemical Property of (E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester

Chemical Property:

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Technology Process of (E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester

There total 1 articles about (E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7) + 4-bromo-benzaldehyde (1122-91-4) → (E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester (1169983-78-1)

Guidance literature:

DL-2-phenylglycine methyl ester hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

4-bromo-benzaldehyde; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2015.02.044

Reference yield: 87.0%

(E)-[(4-bromo-benzylidene)-amino]-phenyl-acetic acid methyl ester (1169983-78-1) + dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → (2S,3S,4R,5S)-trimethyl 5-(4-bromophenyl)-2-phenylpyrrolidine-2,3,4-tricarboxylate (1022349-93-4)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; C₂₈H₂₇Br₂F₁₂N₂P; triethylamine; In dichloromethane; at 0 ℃; for 12h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/ja807669q

upstream raw materials:

DL-2-phenylglycine methyl ester hydrochloride

4-bromo-benzaldehyde

Downstream raw materials:

(2S,3S,4R,5S)-trimethyl 5-(4-bromophenyl)-2-phenylpyrrolidine-2,3,4-tricarboxylate